Everton will host the Merseyside derby at Goodison Park for the first time on 26 March.
The derby had been scheduled for Goodison Park in 2020 with the match being called off due to bad weather and later, the season being affected by the Covid-19 pandemic.
Everton won 3-0 in the reverse fixture which was played at Anfield back in September last year.
Everton have played at Goodison Park twice and the derby, will be their third time at the venue.